DO-ABLE

• Research type

  Research Study

• Full title

  An exploration of Direct Oral Anticoagulant therapy and BLeeding Events in Grampian: a data linkage study (DO-ABLE)

• IRAS ID

  350004

• Contact name

  MJ Macleod

• Contact email

  m.j.macleod@abdn.ac.uk

• Sponsor organisation

  University of Aberdeen

• Duration of Study in the UK

  1 years, 1 months, 31 days

• Research summary

  Prescribing of direct oral anticoagulants (DOACs) has increased in Scotland year on year since 2014, replacing warfarin as the anticoagulants of choice for patients with non-valvular atrial fibrillation (AF) and venous thromboembolism. The incidence of ICH has increased since 2019, and some of this may be due to increased use of anticoagulants.
  To explore this, we will produce a linked dataset of all patients in Grampian dispensed DOACs from 2015 – 2023 and describe the incidence, characteristics and outcomes of those admitted to hospital with bleeding events. We aim to publish this.

• REC name

  North West - Greater Manchester East Research Ethics Committee

• REC reference

  25/NW/0047

• Date of REC Opinion

  26 Feb 2025

• REC opinion

  Favourable Opinion