DMI Study
Research type
Research Study
Full title
A prospective study of structure-function correlation in patients with diabetes with varying sizes of foveal avascular zone.
IRAS ID
254164
Contact name
Sobha Sivaprasad
Contact email
Sponsor organisation
Moorfields Eye Hospital
Duration of Study in the UK
2 years, 5 months, 30 days
Research summary
Summary of Research
Diabetic retinopathy is one of the leading causes of blindness worldwide. One of the main cause of visual loss in patients with diabetes is blockage and loss of blood vessel network at the center of retina.This can affect fine detailed vision that is used for activities such as sewing, reading and driving.
There is no treatment available for this condition and there is limited information available about the progression over time. Dye test for back of the eye has been recognized as the gold standard tool for diagnosis until recent time. However, with the advent of the new machine called OCT angiogram it has become the emerging tool to obtain same information as the traditional angiogram.
In diabetic retinopathy the nerve supplying the cells of the back of the eye get affected before the light sensitive cells. Microperimetry is a form of test that will help us to assess such damage by measuring the light sensitivity of retinal cells.
Participants will be seen at 12, 24, 52 weeks and data will be collected at each visit. This will include eye examination, multiple visual function tests, images of the back of the eye and one time test for blood sugar level assessment.Summary of Results
This study enrolled patients with non-perfusion of the central retina(macula). We looked at the natural history of these patients over 12 months by observing the changes in vision and associated structural and functional changes of the retina. These changes were assessed at baseline,12 weeks,24 weeks and 52 weeks. Among the eyes that lost vision by 5 or more letters over the study period, the disease characteristics were analysed and predictive baseline factors responsible for visual loss were investigated.
Currently there are no treatment options for improving the non perfusion of the retina and understanding the natural history in detail would guide in designing the treatment trials for it. With this study, we also proposed various markers (structural and functional) that will help with identifying the target patient groups who would maximally benefit from treatment and hence form the ideal cohort for the clinical trials. Finally some suggestions for improving the diagnostic accuracy of the structural characters measured via various imaging techniques were also suggested, so that the quality of the data generated is more precise.REC name
HSC REC A
REC reference
19/NI/0030
Date of REC Opinion
25 Feb 2019
REC opinion
Further Information Favourable Opinion