DLB-PSG
Research type
Research Study
Full title
Does non-rapid eye movement sleep differ in dementia with Lewy bodies? A home polysomnography study (DLB-PSG)
IRAS ID
307601
Contact name
Lyndsey Dixon
Contact email
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Dementia with Lewy bodies (DLB) is the second most common form of dementia. Sleep problems are a common feature of DLB, and the best-understood sleep symptom in DLB is rapid eye movement (REM) behaviour disorder, where people appear to act out their dreams during REM sleep. However, we do not know much about what happens during non-REM sleep in people with DLB.
There are two relevant features of brain activity that occur during non-REM sleep; these are known as sleep spindles and slow-wave sleep. These features of sleep originate from parts of the brain that are affected by DLB. Additionally, these features of sleep are very strongly associated with attention, learning and memory, which is impaired in people with DLB.
In this study, we will measure brain activity during sleep in people with DLB, Alzheimer’s dementia (AD) and people without dementia, using a non-invasive technique called polysomnography. We will examine if these features of non-REM sleep are different in DLB and AD, and if they are associated with learning and memory in DLB.
We expect that sleep spindles and slow-wave sleep will be different in DLB. This might help us to use home-based sleep monitoring to improve the diagnosis of DLB.REC name
Wales REC 1
REC reference
22/WA/0057
Date of REC Opinion
28 Mar 2022
REC opinion
Further Information Favourable Opinion