Diversity of S. aureus carrying the Panton-Valentine Leukocidin genes
Research type
Research Study
Full title
The Diversity of Staphylococcus aureus carrying the Panton-Valentine Leukocidin (PVL) genes, within the Gloucestershire area.
IRAS ID
222557
Contact name
Jonathan A Lewis
Contact email
Sponsor organisation
University of the West of England
Duration of Study in the UK
0 years, 4 months, 20 days
Research summary
The objective of the study is to investigate the diversity of the strains of methicillin-sensitive and methicillin-resistant Staphylococcus aureus that carry the Panton-Valentine Leukocidin genes from within the Gloucestershire area and observe if there are any predominant strains. Staphylococcus aureus is an important cause of hospital and community acquired infections. By monitoring the variety of strains within the local area an assessment can be made of the spread of Staphylococcus aureus and observe if there is a strain that is particular to this area. The study will also analyse the demographic information (year of birth, postcode, hospital and community patients and type of sample ( e.g. nose/groin blood culture isolates, wounds, pus)) to see if this correlates with strain typing results. The demographic information associated with the isolates will be anonymised by an independent member of staff. The study will also develop and optimise real-time polymerase chain reaction (PCR) assays for the detection of the various genes of Staphylococcus aureus.
REC name
West of Scotland REC 5
REC reference
17/WS/0062
Date of REC Opinion
21 Mar 2017
REC opinion
Favourable Opinion