DIVA – Diabetes Variants Study
Research type
Research Study
Full title
DIVA – Diabetes Variants Study
IRAS ID
170331
Contact name
Fredrik Karpe
Contact email
Duration of Study in the UK
4 years, 11 months, 31 days
Research summary
Type 2 diabetes (T2DM) is a common disease characterised by having high blood sugar and not enough insulin to meet the bodies requirements. T2DM has a high degree of heritability (runs in families) and the genetic background of an individual is thought to determine the susceptibility to environmental effects and this determines if they get the disease. Recently research looking at the DNA (genetic code or information that tells the cells of the body what to do is) has found specific spots in the DNA that might be causing T2DM. This study aims to find out if the genes found in that research are actually causing T2DM, and how they contribute to people getting T2DM.
This study will do this by inviting healthy participants from the Oxford BioBank with the genes of interest to come, into the Clinical Research Unit, and have different physiological parameters (parameters linked to diabetes) compared to healthy controls. This will provide insight into how the gene change causes diabetes risk. It may also demonstrate new pathways that could be targeted by drugs to improve care. In addition knowledge regarding which pathways are affected may allow personalized treatment.
REC name
South Central - Oxford B Research Ethics Committee
REC reference
15/SC/0072
Date of REC Opinion
12 Mar 2015
REC opinion
Further Information Favourable Opinion