DIScOVER Version 1
Research type
Research Study
Full title
Comparing disability in activities of daily living over time among adults with advanced lung cancer or respiratory disease
IRAS ID
271894
Contact name
Lucy Fettes
Contact email
Sponsor organisation
King's College London
Clinicaltrials.gov Identifier
N/A, N/A
Duration of Study in the UK
1 years, 6 months, 0 days
Research summary
In this research study we want to understand and compare trajectories of disability in activities of daily living (ADL) in adults with advanced lung cancer or respiratory disease.
This is important because people are living longer with advanced lung cancer or respiratory disease due to an aging population and advances in treatment prolonging survival. This may change the illness trajectory of these conditions in terms of pro-longing symptoms and disability. Disability in advanced disease has a specific effect on a person’s ability to perform ADLs, limiting a patient’s independence and quality of life, impacting on care needs.
This study will compare how ADL disability changes over time between patients with advanced lung cancer or respiratory disease and how it relates to symptom severity and use of assistive devices (e.g. walking-frame). It will recruit these patients and their carers from hospital/hospice inpatient, outpatient or community services. Following written consent participants will complete a series of questionnaires about their ability to perform ADLs, current symptoms, use of assistive devices and health care services. There will be 6 self-reported questionnaires at monthly time-points over 6-months. Each questionnaire will take 30-60 minutes to complete and will be returned by post.
By following people prospectively over time, we will be able to evaluate how ADL disability changes, what influences these changes, who it affects, and whether ADL disability can be modified and how, in order to improve outcomes for these disease groups. This will inform development and delivery of appropriate interventions and trial design, which will ultimately inform appropriate and timely services addressing ADL disability in advanced disease.
Patient and public involvement (PPI) representatives have advised on the development of this study from the beginning, and an advisory group including PPI reps will oversee the study throughout.
REC name
London - Camberwell St Giles Research Ethics Committee
REC reference
19/LO/1950
Date of REC Opinion
11 Feb 2020
REC opinion
Further Information Favourable Opinion