DISCOVER
Research type
Research Study
Full title
Reducing risk of stroke and DementIa In patientS with COVert cERebrovascular disease: a pilot and development study (DISCOVER)
IRAS ID
342850
Contact name
William Whiteley
Contact email
Sponsor organisation
University of Edinburgh
Clinicaltrials.gov Identifier
Clinicaltrials.gov Identifier
Clinicaltrials.gov, NCT06878430
Duration of Study in the UK
1 years, 6 months, 4 days
Research summary
The DISCOVER study looks at people who have signs of small blood vessel disease in the brain, found by chance on brain scans. This condition is called covert cerebrovascular disease (CCD). The study aims to find the best ways to invite people with CCD to take part in research and follow up with them. The results will help plan future studies on treatments to lower the risk of stroke or dementia in people with CCD.
We will send letters to 1,000 people who have CCD seen on routine brain scans but have never had a stroke, mini-stroke, or dementia. We expect about 10% to respond, giving us around 100 participants. At the same time, we will ask NHS Lothian doctors to help find more people with CCD.
People who are interested in taking part can talk to the research team. They can choose to meet in person to give consent.
Once enrolled, participants will:
- Complete a questionnaire and some will have an interview about why they chose to take part or not.
- Have simple tests to check memory, speech, and physical abilities.We will follow up with participants by phone at 3, 6, and possibly 12 months. We will also use their medical records to check for any cases of dementia, stroke, heart attack, or other health events.
REC name
West of Scotland REC 3
REC reference
25/WS/0109
Date of REC Opinion
1 Aug 2025
REC opinion
Unfavourable Opinion