DISCARD3
Research type
Research Study
Full title
Implementation of Optical diagnosis of diminutive colorectal polyps in real life clinical practice: Detect InSpect ChAracterise Resect and Discard (DISCARD3)
IRAS ID
245862
Contact name
Brian Saunders
Contact email
Sponsor organisation
R&D, London North West University Healthcare NHS Trust
Duration of Study in the UK
2 years, 0 months, 2 days
Research summary
Colorectal cancer (CRC) is a leading cause of morbidity and mortality in the Western world and the third most common cancer in the UK. Currently all diminutive polyps are resected and examined histologically even though the majority of them are hyperplastic. Therefore, many polypectomies are performed unnecessarily, increasing procedure-related risks such as bleeding and perforation. White light technology, used at routine colonoscopy, is not accurate enough for optical diagnosis to replace routine histopathological assessment. A number of image-enhancing, user-friendly technologies have been developed to enhance the vascular structure of polyps and better characterise them. The Preservation and Incorporation of Valuable Endoscopic Innovations (PIVI) has issued advice on the performance thresholds that these technologies should meet before adoption into clinical practice. The aim of this work is to assess the acceptability and feasibility of optical diagnosis-led care in bowel cancer screening patients undergoing colonoscopy. Previous studies looking into implementation of Real-Time optical diagnosis of small polyps in routine clinical practice have failed to meet these thresholds. This study will determine whether experienced bowel cancer screening colonoscopists are able to consistently record and diagnose diminutive adenomas suitable for a resect and discard strategy allowing assignment of surveillance intervals according to PIVI criteria.
REC name
East of England - Cambridge South Research Ethics Committee
REC reference
19/EE/0234
Date of REC Opinion
21 Nov 2019
REC opinion
Further Information Favourable Opinion