DIMENSION-KD_Version 01 01.01.2018
Research type
Research Study
Full title
Investigating lifestyle determinants of muscle and physical function, and the impact on patient experience and support needs in kidney disease
IRAS ID
242263
Contact name
Alice Smith
Contact email
Sponsor organisation
University Hospitals of Leicester
Duration of Study in the UK
5 years, 0 months, 1 days
Research summary
People with kidney disease (KD) have a loss of kidney function. Poor kidney function is related to other health problems such as diabetes and high blood pressure. Patients also suffer from poor physical functioning, low levels of physical activity, and increased levels of disability. This makes doing everyday activities difficult and reduced their quality of life. Patients have many symptoms such as muscle wasting, severe tiredness, and pain.
KD patients are required to make self-imposed changes to their lifestyle to accommodate their diagnosis. This included changing their diet and taking medication. Many public health recommendations emphasize the importance of a ‘healthy lifestyle’. This could include stopping smoking, eating better, and doing exercise. These are ‘modifiable’ factors (i.e. we can change them) and have been shown to help improve the health of KD patients. These factors are simple targets for potential intervention. However, further research is needed to identify the important lifestyle factors impacted by KD, as well as understanding the needs of the patient.
This study aims to investigate the role and differing impact of KD and basic lifestyle factors on patient’s physical function, symptoms, healthcare usage, and muscle function. It will also explore the patient ‘living experience’ of KD and the impact and role of lifestyle. The study is divided into 3 parts. In Part A, at least 200 will patients fill in a series of questionnaires designed to measure and identify lifestyle determinants and factors associated with living with KD. Part B (optional part) will further explore and detail patient’s body composition (such as fat and muscle mass, muscle quality), physical function and strength, potential markers in the blood, and physical activity levels. Part C (optional part) will involve interviewing patients to find out their needs and explore the in-depth ‘living’ experience and impact of KD on lifestyle.
Summary results: https://gbr01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fclick.pstmrk.it%2F3ts%2Fwww.isrctn.com%252FISRCTN84422148%253Fq%253DDIME%2526filters%253D%2526sort%253D%2526offset%253D3%2526totalResults%253D3%2526page%253D1%2526pageSize%253D10%2FNBTI%2Fz8C5AQ%2FAQ%2F241e0238-05b5-4c2e-93bc-7e15031b14fd%2F3%2FCNdDz7G1PA&data=05%7C02%7Cleicestercentral.rec%40hra.nhs.uk%7C05f09dac64304ba95ddb08dd12ec5c92%7C8e1f0acad87d4f20939e36243d574267%7C0%7C0%7C638687528568055683%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&sdata=Ya1E%2F2DHbdzEe8nt%2FM43Jd%2FcSeZLzD4%2BLAL94WNVVUY%3D&reserved=0REC name
East Midlands - Leicester Central Research Ethics Committee
REC reference
18/EM/0117
Date of REC Opinion
14 May 2018
REC opinion
Favourable Opinion