DIFUS-T1
Research type
Research Study
Full title
Defining the incidence of Cardiac involvement in Myositis using mapping based Cardiovascular Magnetic Resonance Imaging
IRAS ID
222888
Contact name
Daniel Sado
Contact email
Sponsor organisation
King's College Hospital NHS Trust, R+D Manager
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
Inflammatory myopathies are a rare group of conditions occurring as a result of the human body making antibodies to its own tissue (autoimmune disease). They cause skeletal muscle weakness, but can also sometimes affect heart muscle, resulting in inflammation and potentially scarring. When this happens the results can be catastrophic to patients both in terms of symptoms and eventually death.
Study of the heart in these conditions has been limited because most clinical techniques cannot detect changes in the heart muscle unless the disease is severe. New cardiovascular magnetic resonance techniques which we have used in other, similar, conditions could potentially change this and therefore this project aims to assess their use in inflammatory myopathies.
The use of these new techniques will help to accurately identify which patients suffering from Myositis have involvement of their heart muscle thereby offering the possibility of early or more aggressive therapy. We hope it will also provide a useful way of monitoring the activity of the disease within the heart.
REC name
East of England - Essex Research Ethics Committee
REC reference
17/EE/0294
Date of REC Opinion
17 Jul 2017
REC opinion
Favourable Opinion