Different levels of BiPAP
Research type
Research Study
Full title
Crossover study of the work of breathing at different levels of BiPAP settings in neonates
IRAS ID
327794
Contact name
Theodore Dassios
Contact email
Sponsor organisation
King's College Hospital Foundation Trust
Duration of Study in the UK
0 years, 7 months, 1 days
Research summary
Bilevel continuous positive airway pressure (BiPAP) is a type of non-invasive respiratory support which can be used as breathing support in neonates requiring some pressure support to help their breathing. BiPAP provides cycles of higher and lower pressure levels at set intervals, usually with a baseline pressure constant of 5cm H2O.
In the UK, other forms of non-invasive ventilation, such as NIPPV and NIV-NAVA, have been shown to be efficacious , however they are expensive. BiPAP may therefore provide a viable and cost-effective alternative. Currently there are no written guidelinesabout BiPAP use.
We aim to identify the most efficacious BiPAP settings for preterm infants as primary support and post-extubation as well as in those with evolving BPD. Infants will be studied at three different upper pressure settings for a period of 20 minutes each. The work of breathing will be measured from small pressure transducers situated on a thin catheter, the size of a feeding tube. The catheter will be passed through the mouth and positioned so the tip is in the stomach. Following the study the infant will subsequently be nursed on the breathing support type associated with the lower work of breathing.REC name
North West - Greater Manchester Central Research Ethics Committee
REC reference
23/NW/0376
Date of REC Opinion
9 Jan 2024
REC opinion
Further Information Favourable Opinion