Dietry compliance in coeliac disease.
Research type
Research Study
Full title
An investigation into dietary compliance of patients with coeliac disease
IRAS ID
159160
Contact name
Humayun Muhammad
Contact email
Sponsor organisation
Roehampton University
Clinicaltrials.gov Identifier
UNiversity Hospitals of Leicester Ethics Ref No, UHL 11341; Roehampton University Ethics Ref No, LSC 14/ 112
Duration of Study in the UK
0 years, 2 months, 18 days
Research summary
Coeliac disease (CD) is a disorder of the gastrointestinal system where an allergic reaction to gluten (found in wheat and related products) leads the inflammation of the inner lining of the small bowel. This in turns leads to mal-absorption resulting in anaemia, and may lead to skin disorder, cancer and bone disease. Avoiding gluten is the only practical way to counteract this allergic reaction. Patients with coeliac disease are offered strict Gluten free diet (GFD).
The diet itself is not easy to follow and there are compliance related issues in patients with CD. Compliance is low in Asian patients as shown by one previous study in 2004 (Butterworth et; al) and subsequently in my Pilot Msc project (Muhammad 2012). The MSc project suggested that changes to be made to the design, modify delivery method of the validated questionnaire and a more extensive study should be undertaken which takes into account a larger cohort (1000 this time). In this study clinical data supplemented by clinical letters and laboratory investigation will also be analysed for more objective results.
We have an extensive cohort of coeliac disease in Leicester and 10 to 15 % of them are Asian. We can now expand our study with slightly different methodology to verify the results or otherwise. This will aid us in helping patients to increase their compliance in future studies by finding out the causes behind the low compliance. This can reduce the burden of active disease. Suppressing disease activity may result in patients’ physical and psychological improvement and economic benefits for the NHS.REC name
London - Queen Square Research Ethics Committee
REC reference
14/LO/2128
Date of REC Opinion
27 Nov 2014
REC opinion
Favourable Opinion