Dietary polyphenols and glycation in renal insufficiency
Research type
Research Study
Full title
PoGlyDRI - Impact of Dietary Polyphenols on Protein Glycation in Type 2 Diabetes Mellitus Subjects with Chronic Renal Insufficiency
IRAS ID
166822
Contact name
Nora Alshammari
Contact email
Sponsor organisation
University of Glasgow
Clinicaltrials.gov Identifier
Duration of Study in the UK
4 years, 5 months, 1 days
Research summary
Type 2 diabetes mellitus (T2DM) is associated with an increased risk of complications such as kidney failure. In Scotland, 0.5% of T2DM subjects have end-stage renal disease (ESRD). In the diabetic kidney, there is a decrease clearance capacity caused by the high levels of glucose, that leads to increased inflammation, oxidative stress, and glycation. Individuals with high levels of glycohaemoglobin (HbA1c) present a sharper decline in renal function. As renal function declines, the risk of mortality and ESRD increases.
Epidemiological studies postulate that decreasing the levels of oxidative stress and glycation could result in a significant suppression of diabetes-associated nephropathy changes. Polyphenols have been proposed as a potential vector to ameliorate renal insufficiency in diabetic subjects, by reducing the histopathological damage. Epidemiological studies have shown that a higher intake of polyphenols (≥201 mg/d) is associated with 50% lower risk of renal insufficiency, 65% lower risk of experiencing a renal disease event and reduced 20-40% all-cause mortality, compared to a low polyphenol diet (<141mg/d).
Chlorogenic acids (CGA) are one of the principle polyphenol groups in the diet. CGA is the main polyphenol in coffee and tea, and so is in stone fruits (especially plums / prunes) and some vegetables (artichoke, chicory). CGA (3-4 cups of coffee) has been associated with 25% lower risk of T2DM. CGA has shown a favourable reduction of HbA1c, blood pressure, and oxidative stress levels.
Hence, the hypothesis is that if CGAs have a positive effect on glycation and oxidation, the progression of renal insufficiency can be reduced. Therefore, the present study aims to evaluate the effect of a high CGA food on glycation and oxidative stress in T2DM subjects with early renal insufficiency (glomerular filtration rate of 35–60 mL/min) as well as progression of renal insufficiency and the risk of cardiovascular diseases.
REC name
West of Scotland REC 1
REC reference
15/WS/0150
Date of REC Opinion
15 Oct 2015
REC opinion
Further Information Favourable Opinion