Dietary manipulation in cystic fibrosis-related diabetes
Research type
Research Study
Full title
Dietary manipulation to improve glycaemic control in young people with cystic fibrosis-related diabetes/impaired glucose tolerance: A feasibility study
IRAS ID
167956
Contact name
Laura Birch
Contact email
Sponsor organisation
University of Bristol
Duration of Study in the UK
0 years, 6 months, 0 days
Research summary
Improvements in life expectancy in cystic fibrosis mean that cystic fibrosis-related diabetes is becoming an increasingly important complication, as the prevalence of impaired glucose tolerance and diabetes increases with age. Treatment regimes for people with cystic fibrosis are demanding, impacting significantly on daily life. Developing cystic fibrosis-related diabetes has important implications and further complicates cystic fibrosis management through daily blood tests and insulin injections. From diagnosis, people with cystic fibrosis are encouraged to consume an energy dense diet high in fat and sugar to maintain their weight, but high sugar intakes can lead to poor glycaemic (blood sugar) control in people with impaired glucose tolerance or diabetes.
This study will explore the feasibility of dietary manipulation to improve glycaemic control in a sample of 10 young people with cystic fibrosis-related diabetes/impaired glucose tolerance, under the care of Bristol cystic fibrosis services. A dietary manipulation plan with the aim of improving glycaemic control whilst maintaining the energy content of the diet will be developed and implemented by participants for two weeks. Dietary intake and glycaemic control will be measured pre- and post-implementation of the manipulated diet using an on-line dietary recording tool and continuous glucose monitoring, respectively.
The primary outcomes of this study are feasibility and acceptability. Feasibility will be assessed through recruitment to the study and retention of participants, and acceptability of the dietary manipulation will be assessed through semi-structured interviews after the implementation period. The effectiveness of the dietary manipulation will be assessed as a secondary outcome, measured by change in glycaemic control and total energy content of the diet.
REC name
East Midlands - Leicester Central Research Ethics Committee
REC reference
15/EM/0185
Date of REC Opinion
8 Jun 2015
REC opinion
Further Information Favourable Opinion