Diaphragm EMG in preterm infants at different flow rates of HHHFNC
Research type
Research Study
Full title
A crossover study comparing the diaphragm EMG measurements of preterm infants during differing flow rates of oxygen delivered through heated humidified high flow nasal cannula
IRAS ID
237675
Contact name
Anne GReenough
Contact email
Sponsor organisation
King's College London
Duration of Study in the UK
0 years, 6 months, 1 days
Research summary
Over 22 200 live infants are born each year in the UK at or under a gestational age of 34 weeks. Many of these infants require respiratory support. This includes both invasive mechanical ventilation and non-invasive ventilation (NIV).
This study, conducted at a tertiary neonatal intensive care unit, will look at neonates born at 34 weeks or less with respiratory insufficiency who require respiratory support provided by heated humidified high flow nasal cannula (HHHFNC), one form of non-invasive ventilation. The project will be looking at three flow rates of HHFNC: 4l/min, 6l/min, 8l/min.
The infants will be cycled through all three flow rates, with treatment for one hour at each one. At the end of the hour, there will be a 5 minute recording of diaphragmatic EMG. This doesn't directly measure work of breathing but is a good predictor of it. The aim is to determine whether the diaphragm EMG measurement (as a predictor of work of breathing) is lower with increases in flow rate provided by heated humidified high flow nasal cannula (HHHFNC). The babies will be randomised to one of 6 groups starting with 4, 6 or 8l/min, allowing for all combinations.REC name
Wales REC 5
REC reference
18/WA/0077
Date of REC Opinion
23 Feb 2018
REC opinion
Favourable Opinion