Diaphragm EMG during caffeine loading in ventilated preterm infants
Research type
Research Study
Full title
Changes in the diaphragm EMG following the first dose of caffeine in ventilated preterm infants
IRAS ID
231223
Contact name
Anne Greenough
Contact email
Sponsor organisation
King's College London
Duration of Study in the UK
0 years, 9 months, 31 days
Research summary
Preterm infants may develop apnoea, or pauses in breathing that result in decreased blood oxygen levels. Caffeine is routinely given to prematurely-born infants to reduce apnoea and improve outcomes. Premature babies who need help from a breathing machine are routinely given caffeine when preparing to remove this support and allow them to breathe on their own. We are interested in whether giving caffeine to babies whilst they are still receiving support from the breathing machine changes the electrical activity of the diaphragm, which is the main breathing muscle, and how this might change the amount of ventilator support that they require.
REC name
London - West London & GTAC Research Ethics Committee
REC reference
17/LO/1796
Date of REC Opinion
30 Oct 2017
REC opinion
Unfavourable Opinion