Diaphragm EMG during caffeine loading in ventilated preterm infants
Research type
Research Study
Full title
Changes in the diaphragm EMG following a loading dose of caffeine in ventilated preterm infants
IRAS ID
231223
Contact name
Anne Greenough
Contact email
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Premature babies are routinely given caffeine, which can help to increase respiratory drive and improve outcomes. We are interested in how giving the first dose of caffeine (a 'loading' dose) to babies whilst they are still receiving support from the breathing machine changes the electrical activity of the diaphragm, which is the main breathing muscle, and how this might affect the ventilation that they are receiving.
This is particularly important as newer forms of ventilation are being devloped that use the electrical activity of the diaphragm to control the ventilator, and therefore it is vital that we understand how caffeine might affect this.REC name
London - Brent Research Ethics Committee
REC reference
18/LO/0925
Date of REC Opinion
23 Jul 2018
REC opinion
Further Information Favourable Opinion