Diagnostic Investigation and Prediction of Shock v1.0
Research type
Research Study
Full title
Diagnostic Investigation and Prediction of Shock (The DiPS Study)
IRAS ID
215064
Contact name
Timothy H Rainer
Contact email
Sponsor organisation
Cardiff University
Clinicaltrials.gov Identifier
Duration of Study in the UK
0 years, 11 months, 31 days
Research summary
The aims of our study are to investigate whether advanced physiology using an ultrasound device called USCOM predicts survival and admission to ICU within 7 days of ED presentation; whether the USCOM variables improve the detection and classification of shock; to validate and refine a method called ‘LiPS’ for detecting and classifying shock; and to evaluate whether doctors can accurately detect shock.
Patients come to Emergency Departments (ED) with a spectrum of life-threatening illness. Missing the severity of illness leads to under-treatment, avoidable death, and unnecessary hospital costs. One centre in Australia was able to reduce the death rate for septic shock from 38% to 7% using an Uscom strategy. We would like to evaluate whether the same would occur if applied across EDs in Wales. However, before we can do that we need to strengthen our understanding of heart physiology measurement, and of relevant protocols and non-invasive devices that help us to acquire such information.
After ethics and institutional approval is obtained we will conduct a prospective, single-centre, cohort study on 354 adult patients with possible shock associated with an acute illness or injury who present to the ED of the University Hospital of Wales, and follow them up for 7 days. 354 is a credible number to confirm that the strategy works.
We expect to discover that some of the 21 Uscom variables predict 7-day survival and ICU admission and improve the detection and classification of shock, and that patients have a good experience and are satisfied with care
Patients in the study will be identified for their opinion of the study. Patients will also be sought to join the Trial Management Group (TMG) as a co-applicant overseeing future studies.REC name
Wales REC 2
REC reference
17/WA/0207
Date of REC Opinion
16 Jul 2017
REC opinion
Favourable Opinion