Diagnostic and prognostic markers of acute Ischaemic stroke
Research type
Research Study
Full title
Diagnostic and Prognostic markers of Stroke Outcomes
IRAS ID
50831
Contact name
Kirti Kain
Contact email
Sponsor organisation
Faculty Head of Research and Innovation Support, FMH Research office
Clinicaltrials.gov Identifier
NA, NA
Duration of Study in the UK
7 years, 11 months, 30 days
Research summary
The diagnosis of stroke remains largely clinical, yet widely used stroke scoring systems do not allow distinction of patients with acute stroke from those with mimic presentations (e.g., migraine, seizures, infections and mass brain lesions). Only 60% of patients who are triaged as FAST+ by ambulance services are subsequently confirmed to have suffered an acute stroke (LTHT audit data). In hospital a ROSIER test (tool to enable staff to differentiate between stroke and stroke mimics clinically) adopted by frontline Emergency Department (ED) staff may add more specificity, but this is found to be variable dependent on experience and level of training. In hospital, a simple routine computed tomography (CT) scan can reliably confirm haemorrhage. The proportion of patients with mini-stroke (lasting less than 24 hours) as opposed to a mimic is even lower than that confirmed to be true stroke. It is believed that biomarkers in body fluids may be one of the keys to address this problem. The most pressing need for a diagnostic biomarker is in the ultra-acute phase when patients are assessed by paramedics out of hospital or by emergency physicians in the accident and emergency department (A&E), as this is where the most important time critical decisions have to be made.\nThe aims of the study are to quantify brain/ blood brain damage, imaging and insulin resistance markers which \n\n1. distinguish between acute stroke and stroke mimic patients\n2. differentiate between ischaemic and haemorrhagic stroke\n3. differentiate between small vessel disease and large vessel disease\n4. robust predictors of early and longer term stroke outcomes\n5. association with perfusion of the brain and the legs\n6. differences in the all of the above between Europeans and other populations.\n\nAll the above answers would enable treatments to be targeted more effectively at an early stage of stroke.\n
REC name
Yorkshire & The Humber - Leeds East Research Ethics Committee
REC reference
19/YH/0232
Date of REC Opinion
1 Nov 2019
REC opinion
Further Information Favourable Opinion