Diabetes BFX Sampling study

• Research type

  Research Study

• Full title

  Diabetes Blood Factor X Sampling Study

• IRAS ID

  305555

• Contact name

  Calum Sutherland

• Contact email

  c.d.sutherland@dundee.ac.uk

• Sponsor organisation

  University of Dundee

• Duration of Study in the UK

  3 years, 0 months, 1 days

• Research summary

  An early feature of Type 2 Diabetes (T2D) is a progressive reduction in whole-body insulin sensitivity (insulin resistance). This appears even before the development of T2D, which occurs when insulin secretion no longer overcomes the underlying insulin resistance, resulting in hyperglycaemia. There are many potential molecular mechanisms leading to whole body insulin resistance.
  This study is designed to collect blood samples from appropriate groups of volunteers. These samples will permit lab based (funded) experimental studies to investigate the molecular basis of serum-mediated generation of insulin resistance via the following strategies:
  • What is the nature of the blood borne factor(s)?
  • Is the observed insulin resistance tissue-specific?
  • Does the insulin resistance generation in culture correlate with any clinical features of the individual donors?
  

• REC name

  London - West London & GTAC Research Ethics Committee

• REC reference

  21/PR/1385

• Date of REC Opinion

  29 Oct 2021

• REC opinion

  Further Information Favourable Opinion