Device for detection of immune cells as indication of infection
Research type
Research Study
Full title
Development of a device for detection of human immune cells as an indicator of infection
IRAS ID
315804
Contact name
Nishal Govindji-Bhatt
Contact email
Sponsor organisation
Microbiosensor Ltd
Duration of Study in the UK
2 years, 4 months, 31 days
Research summary
Microbiosensor are developing point-of-care devices that can detect immune cells, also called white blood cells (WBC) in clinical samples. We currently collect these clinical samples from various hospital sites. However, often clinical samples directly relevant to the device are often not appropriate for initial optimisation experiments in the laboratory. This is because the number of white blood cells can vary and there can be interfering cells, such as red blood cells, that often make working with clinical samples for optimisation of the device challenging.
Often a small volume of fresh whole human blood has significant numbers of all the cell types typically found in clinical samples, which can therefore be used in optimisation experiments in a more controlled manner, because in healthy human blood, the proportions of the different cell types are well characterised. In this study, we will separate out the different types of cells present, to test different concentrations and combinations of these on the devices. We would also like to use different concentrations of RBC to optimise a method for removing these cells as they otherwise interfere with the reading of WBC.REC name
East of England - Cambridge South Research Ethics Committee
REC reference
22/EE/0239
Date of REC Opinion
12 Dec 2022
REC opinion
Further Information Favourable Opinion