Development of cell based models of uveal melanoma
Research type
Research Study
Full title
Development of cell based in vitro and in vivo models of uveal melanoma
IRAS ID
154552
Contact name
Sarah Coupland
Contact email
Sponsor organisation
University of Liverpool
Duration of Study in the UK
1 years, 3 months, 30 days
Research summary
Uveal melanoma is a very rare type of eye cancer. In approximately fifty percent of individuals suffering from this cancer, it will eventually spread to the liver, which is fatal. There are currently no effective treatments once the cancer has spread to the liver. To have a better understanding of and to be able to treat this disease, models are required that mimic the disease and which can be used to carry out drug tests. In this study we will use primary uveal melanoma cells isolated from patient tumour specimens to reflect the molecular and clinical diversity seen in uveal melanoma. The cells will be examined both in an in vivo chick embryo model system and growing as 3D cultures in vitro. Endpoints to be examined include growth rate, blood vessel recruitment and migratory capacity. The ultimate goal of these studies is to develop an integrated approach for preclinical drug testing.
REC name
South East Scotland REC 01
REC reference
15/SS/0097
Date of REC Opinion
29 May 2015
REC opinion
Favourable Opinion