Development of 3D tissue engineered bone-oral mucosa composite model
Research type
Research Study
Full title
Development of a 3 Dimensional tissue engineered bone-oral mucosa composite model
IRAS ID
158333
Contact name
Thafar Almela
Contact email
Sponsor organisation
Sheffield Teaching Hospital NHS Foundation Trust
Duration of Study in the UK
3 years, 11 months, 31 days
Research summary
Previous research has managed to create a laboratory model of the human mouth which is used as an alternative for animal testing for analysing new dental and oral products for safety. The current project is looking at developing a model which also uses bone which would be more useful in the laboratory. Patients who are having routine dental surgery will be approached to donate their waste tissue. If they are happy to do so consent will be taken and there tissue will anonymously be transferred to the laboratory.
In the laboratory the tissue will be used in three ways:
1. Bone fragments will be cultured to allow bony cells to grow out which can then be used.
2. Oral mucosa will be cultured so that it multiplies then used within the 3D model
3. The bone and mucosa described above will combined together
The model created will undergo various tests to examine how closely it resembles the normal human tissues. We will also assess the response of the composite model to exposure to various materials that come into contact with the oral cavity such as dental materials and dental implants.REC name
London - Hampstead Research Ethics Committee
REC reference
15/LO/0116
Date of REC Opinion
22 Jan 2015
REC opinion
Favourable Opinion