Determinants of cardiovascular disease, kidney disease and diabetes

• Research type

  Research Study

• Full title

  Determinants of Cardiovascular disease, Kidney disease and Diabetes in people of African ancestry with HIV (CKD study).

• IRAS ID

  278244

• Contact name

  Frank Post

• Contact email

  frank.post@kcl.ac.uk

• Sponsor organisation

  King’s College NHS Foundation Trust

• Clinicaltrials.gov Identifier

  N/A, N/A

• Duration of Study in the UK

  1 years, 11 months, 31 days

• Research summary

  Lay summary of study results:
  The CKD-AFRICA study investigated the relationship between Social Determinants of Health and long-term health conditions in people of Black ethnicities living with HIV. Participants completed questionnaires and participated in focus group discussions. We found a strong relationship between adverse socio-economic circumstances, poor mental health, and chronic pain. There were few or no links between socio-economic deprivation and physical health (high blood pressure, obesity, kidney, cardiovascular, lung disease or diabetes). Focus groups revealed challenges in navigating the health care system and provided examples of structural racism as well as excellence in health care.
  Data and samples have been used to look at relationships between waist circumference and metabolic parameters, and various measures of kidney function. Ongoing work focuses on grouping of Social Determinants of Health and the relationship between pain, mobility, quality of life and mental health.

  Cardiovascular disease (CVD), chronic kidney disease (CKD), diabetes mellitus (DM) and HIV infection are long-term conditions (LTC) with major health implications for people of African ancestry. These LTC often arise in the setting of an adverse demographic, social, biologic and genetic environment, although this remains poorly understood. This study aims to evaluate demographic, clinical, social, biologic, genetic factors associated with CVD, CKD and DM and multiple long-term conditions (LTC; >2 of CVD, CKD, DM) in 400 individuals of African ancestry. Study procedures include collection of clinical information, completion of questionnaires, and analysis of blood and urine samples.

• REC name

  London - Westminster Research Ethics Committee

• REC reference

  20/LO/0946

• Date of REC Opinion

  5 Aug 2020

• REC opinion

  Favourable Opinion