Detection of Intestinal Ischaemia (DIXIE)
Research type
Research Study
Full title
Detection of Intestinal Ischaemia (DIXIE) - A Pilot Study for Biomarkers in Intestinal Obstruction.
IRAS ID
280005
Contact name
Matthew J Lee
Contact email
Sponsor organisation
Sheffield Teaching Hospitals NHS FT
Duration of Study in the UK
0 years, 11 months, 31 days
Research summary
Blockage of the small bowel is a common problem for people in the UK, affecting more than 20,000 people each year. It is most frequently caused by scar tissue from previous surgery which causes the bowel to kink and become blocked. Around 1 in 3 people with this problem will require surgery, the rest will get better without an operation. We know from previous research that delays in surgery can lead to worse outcomes. This includes longer stays in hospital, and more difficult or extensive operations.
Surgery is required if the blood supply to the bowel is poor. This is usually detected using a CT scan. However the CT scan is not always sensitive enough to detected early stages of reduced blood flow and so operations can be delayed. It is therefore important to try and find another way of detecting blood flow to the bowel, so clinicians know when it is best to operate.
This research study will use new blood tests to determine if they can detect poor blood flow to the bowel in patients with a small bowel obstruction.
REC name
Yorkshire & The Humber - Bradford Leeds Research Ethics Committee
REC reference
20/YH/0297
Date of REC Opinion
23 Oct 2020
REC opinion
Favourable Opinion