Detection of dysplasia in Barrett’s oesophagus and risk of cancer
Research type
Research Study
Full title
Detection of dysplasia in Barrett’s oesophagus and risk of progression to cancer
IRAS ID
215857
Contact name
Perminder Phull
Contact email
Sponsor organisation
NHS Grampian
Duration of Study in the UK
0 years, 7 months, 24 days
Research summary
There is a rising incidence of adenocarcinoma of the oesophagus in the Western world, with Scotland having one of the highest incidences. Oesophageal cancer is associated with a particularly poor survival – less than 13% at 5 years. Barrett’s oesophagus is a recognised risk factor for oesophageal adenocarcinoma. It is an acquired condition occurring in response to gastro-oesophageal reflux leading to a columnar lined distal oesophagus. Malignancy is thought to arise through the metaplasia-dysplasia-cancer sequence. However, the natural history of dysplasia and the risk of progression to cancer is uncertain with scant published data from Scotland. \n\nTo determine the natural history of dysplasia is Barrett’s oesophagus and risk of progression to cancer.\n\nRetrospective cohort study of patients diagnosed with with Barrett’s oesophagus at our institution between 2007 and 2015.
REC name
North of Scotland Research Ethics Committee 1
REC reference
16/NS/0128
Date of REC Opinion
6 Dec 2016
REC opinion
Further Information Favourable Opinion