Detect study
Research type
Research Study
Full title
Developing tests for endometrial cancer detection
IRAS ID
208785
Contact name
Emma J Crosbie
Contact email
Sponsor organisation
Central Manchester University Hospitals NHS Foundation Trust
Duration of Study in the UK
4 years, 0 months, 1 days
Research summary
Womb cancer is the most common gynaecological cancer in the UK. Most women with womb cancer present early with postmenopausal bleeding. However, only a small proportion of women with postmenopausal bleeding, around 1 in 20, actually have womb cancer. To find out who does, all women with postmenopausal bleeding are referred urgently for investigations, which include an internal scan, a camera test and a biopsy. These investigations are technically difficult in some, painful in others and unnecessary in most. We want to develop a new test that could help to decide who really needs these investigations and who can be safely managed without them.
We want to see whether womb cancer cells can be picked up in the vagina or on the cervix using tests that are routinely used in cervical screening. We would also like to check that these really are womb cancer cells by looking for gene faults, or mutations, that are commonly seen in womb cancer, but not in normal cells. We will use state-of-the-art technology to look for abnormal cells, genetic material, proteins and other substances in blood, urine, cervical and vaginal samples that may improve the diagnosis of future women affected by womb cancer.
REC name
North West - Greater Manchester West Research Ethics Committee
REC reference
16/NW/0660
Date of REC Opinion
5 Sep 2016
REC opinion
Favourable Opinion