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Research type
Research Study
Full title
Development of extracellular vesicle-derived tumour markers by the lipidomic analysis of extracellular vesicles obtained from breast cancer patients and healthy volunteers pre- and post-operatively
IRAS ID
251363
Contact name
Charles Coombes
Contact email
Sponsor organisation
Imperial College London
Duration of Study in the UK
4 years, 0 months, 2 days
Research summary
Exosomes have recently become a popular area of research within the Cancer field due to their crucial role in extracellular communication. Upon their release from cancer cells these may be involved in pathways leading to disease progression. In relation to Breast Cancer this is yet to be explored fully, we are proposing a study with the primary aim of using blood samples from control group undergoing breast surgery. Control group or healthy volunteers in this study is defined as individuals with benign breast disease, and those undergoing bilateral breast reduction. For simplicity a term “PATIENT” will be used every time we refer to a control group/health volunteers.
We are specifically interested to determine the proportion of isolated exosomes in the peripheral blood. To do this, we intend to isolate exosomes from primary breast cancer patients post-operatively (blood samples will be obtain from another study approved by Imperial College Tissue Bank Ref: R17023-3A) and compare it to the exosomes in the peripheral blood of control group post breast surgery. By characterising the lipidome of each sample we should be able to estimate the proportion and type of exosomes that derives from the breast cancer itself, as distinct from other sources.
Patients will be recruited from Breast Clinic at Charing Cross Hospital, Imperial College Healthcare NHS trust.REC name
London - Harrow Research Ethics Committee
REC reference
19/LO/0392
Date of REC Opinion
25 Jun 2019
REC opinion
Further Information Favourable Opinion