Derivation of GMP grade ECFC from umbilical cord blood

• Research type

  Research Study

• Full title

  Derivation of GMP grade endothelial colony forming cells from umbilical cord blood

• IRAS ID

  276846

• Contact name

  Alasdair Fraser

• Contact email

  Alasdair.Fraser@net.net

• Sponsor organisation

  Scottish National Blood Transfusion Service

• Clinicaltrials.gov Identifier

  N/A, N/A

• Duration of Study in the UK

  5 years, 0 months, 0 days

• Research summary

  Endothelial colony forming cells (ECFC) have the clinical potential to promote vascular repair in diseases where restriction in blood supply to the tissue is the main pathological factor. The Scottish National Blood Transfusion Service wish to generate these cells as a cellular therapeutic for the potential treatment of restricted blood flow diseases such as diabetic retinopathy and cardovascular disease. ECFC injected directly into the eye have been shown to successfully repair damaged retinal blood vessels in animal model studies. Therefore, to assess if ECFC can be used to induce vascular repair we need to assess the ability to generate theses cells from umbilical cord blood samples and develop acceptable methods to expand then to clinically relevant numbers, characterise and bank these cells.

• REC name

  London - Brighton & Sussex Research Ethics Committee

• REC reference

  20/HRA/1186

• Date of REC Opinion

  7 Apr 2020

• REC opinion

  Further Information Favourable Opinion