Dental pulp stem cells to repair cranio-facial hard and soft tissue.
Research type
Research Study
Full title
The use of tooth derived mesenchymal stem cells to enhance cranio-facial hard and soft tissue repair and regeneration.
IRAS ID
235591
Contact name
Julian Yates
Contact email
Sponsor organisation
University of Manchester
Duration of Study in the UK
4 years, 0 months, 0 days
Research summary
In this study, we propose to investigate the potential of stem cells from tooth pulp tissue to differentiate into a number of cell types, and in particular, those involved in bone, cartilage and soft tissue regeneration and repair in the cranio-facial region. This is important as this type of research will give an insight into tissue regeneration that can be used for clinical application in cranio-facial repair.
Cranio-facial repair may be after certain conditions such as cystic lesions, cancer, trauma, deformities, inflammatory conditions and so on.
Using techniques including traditional in-vitro culture, hydrogels, composites, implants and 3D digital printing technologies and in-vivo models of tissue regeneration we hope to culture and co-deposit living human DPSC into viable soft and hard tissue constructs.
It is hoped that by developing both existing and new cell culture/proliferation techniques we can produce innovative methods for hard and soft tissue regeneration.
Clinically, teeth are either lost naturally or removed for many reasons – decay, crowding, impaction (wisdom teeth) and orthodontic treatment/braces - and it is because they may otherwise be discarded that we wish to investigate the therapeutic potential of the DPSC contained within in them. Thus we will be asking eligible participants to donate their teeth that otherwise will be discarded after extraction.
This study will be carried out at the University of Manchester and Manchester Metropolitan University research laboratories. Proposed study duration is 4 years.REC name
London - Stanmore Research Ethics Committee
REC reference
19/LO/1712
Date of REC Opinion
24 Oct 2019
REC opinion
Favourable Opinion