Dental assessment prior to allogenic stem cell transplantation
Research type
Research Study
Full title
The influence of dental assessment prior to allogenic stem cell transplantation on patient centred outcomes including graft versus host disease and quality of life.
IRAS ID
224849
Contact name
Amit Patel
Contact email
Sponsor organisation
The Clatterbridge Cancer Centre NHS Foundation Trust
Duration of Study in the UK
1 years, 7 months, 5 days
Research summary
Patients diagnosed with blood cancer (including leukaemia, myeloma or lymphoma), autoimmune disease or congenital immune deficiency may be treated with stem cells from a suitably matched donor. This is a form of transplantation, taking excess stem cells from a healthy donor and replacing the cells and DNA in patient's bone marrow, after preparation with chemotherapy and sometimes additional radiotherapy. Potential complications after this complex procedure can be severe, affecting and mouth and other organs, impacting on the short and long-term quality of life of patients.
Patients will usually receive a dental assessment prior to the stem cell transplant procedure. However, it is unclear if patients benefit from this routine assessment by a special care dentist. To investigate the influence of these dental assessments on patient focused outcomes and quality of life after the transplant procedure using stem cells from a donor a study will be undertaken, in two parts.
The first part will use existing information to investigate if dental treatment prior to a stem cell transplant procedure influences a patient's outcomes after the transplant. This will entail a review of existing patient clinical records to compare dental factors with oral and other systemic patient outcomes.
The second part will collect new information from patient interviews post allogeneic stem cell transplant. These interviews will focus on patient views and their assessment of their quality of life. The results from this study the will be feed back to patients and will be used to develop and improve the dental care received by future patients.
REC name
North West - Liverpool Central Research Ethics Committee
REC reference
18/NW/0043
Date of REC Opinion
17 Apr 2018
REC opinion
Further Information Favourable Opinion