Delivery of adipose-derived regenerative cells during EVNP
Research type
Research Study
Full title
Delivery of adipose-derived regenerative cell therapy during ex-vivo normothermic perfusion of kidneys.
IRAS ID
269613
Contact name
Marc Clancy
Contact email
Sponsor organisation
NRS Research Performance Manager for Renal Portfolios
Duration of Study in the UK
1 years, 6 months, 2 days
Research summary
Ex-vivo normothermic perfusion (EVNP) is a technology for the reconditioning and assessment of transplant kidneys, using oxygenated blood to perfuse the kidney prior to transplantation at the recipient unit. It is used clinically around the UK and has been demonstrated as safe, and improves early kidney function post-transplant (i.e. reduces delayed graft function). It has also been shown to demonstrate a reconditioning capacity with successful transplantation of kidneys that were deemed unusable following treatment with EVNP.
Our unit in Glasgow university has previously demonstrated the ability for regenerative cells which are harvested from adipose tissue (adipose-derived regenerative cells, or ADRCs) to mitigate the effects of ischaemia-reperfusion injury in animal models. These cells are unique, in part, because they do not require cell culture and expansion prior to administration.
This study aims to take this one step further to assess whether ADRC cells can be delivered during EVNP and their effect on the immunogenic environment of the kidney during ex-vivo perfusion as a surrogate for their effects of ischaemia-reperfusion injury.
These kidneys are research kidneys that have been rejected from all clinical transplant units and are reallocated to research centres. These kidneys are not subsequently transplanted.
This work will help guide the body of research around EVNP using a novel therapeutic agent and help to evaluate the potential for treatment during EVNP of kidneys.
REC name
London - Westminster Research Ethics Committee
REC reference
20/LO/0256
Date of REC Opinion
14 Apr 2020
REC opinion
Further Information Favourable Opinion