DEFINE

• Research type

  Research Study

• Full title

  A series of pilot studies to evaluate the haemodynamic and metabolic effects of Apelin and Relaxin in healthy humans, subjects with increased weight and patients with type 2 diabetes mellitus

• IRAS ID

  230996

• Contact name

  Joseph Cheriyan

• Contact email

  jc403@medschl.cam.ac.uk

• Sponsor organisation

  Cambridge University Hospitals NHS Foundation Trust and University of Cambridge

• Duration of Study in the UK

  2 years, 0 months, 0 days

• Research summary

  What is the research question?
  In systemic studies apelin and relaxin will be infused into systemic circulation to investigate their effect on heart and blood glucose level.
  In forearm blood flow studies (FBF), relaxin will be infused into brachial artery to investigate its mechanism of action. Apelin and relaxin will be investigated in FBF to establish their combined effects on vasomotor tone in healthy participants.

  What is being studied?
  Naturally occurring body peptides apelin and relaxin

  Who is eligible?
  There are 3 different populations being looked at for this study. Healthy participants, participants with increased weight, and participants with Type 2 Diabetes Mellitus

  Where will the study take place?
  The study will be conducted at the Addenbrooke's site

  How long will the study last?
  There are 7 sub-studies each with different visit schedules, the minimum duration (including follow-up phone call) would be 2 days while the maximum would be approximatly 13 weeks

• REC name

  Yorkshire & The Humber - Sheffield Research Ethics Committee

• REC reference

  18/YH/0010

• Date of REC Opinion

  29 Jan 2018

• REC opinion

  Favourable Opinion