DECODE II Study

• Research type

  Research Study

• Full title

  DNA Repair in Patients with Stable Angina

• IRAS ID

  261784

• Contact name

  Michael Mahmoudi

• Contact email

  m.mahmoudi@soton.ac.uk

• Sponsor organisation

  University Hospital Southampton NHS Foundation Trust

• Duration of Study in the UK

  2 years, 0 months, 1 days

• Research summary

  The progressive deposition of cholesterol along the wall of one or more of the three main arteries that supply the heart muscle leads to the formation of fatty deposits called coronary atheroma. This can eventually lead to the restriction of blood flow causing patients to experience chest pain when they exert themselves. This condition is called stable angina.
  Over the past decade, there is increasing evidence to suggest that genes and proteins that are responsible for signalling DNA damage and DNA repair may be implicated in the molecular pathways that lead to the development of coronary atheroma. We also have preliminary data that indicates patients with angina may have reduced DNA repair activity in their circulating blood cells called peripheral blood mononuclear cells. The aim of this study is to identify the molecular mechanism and the biological consequences of reduced DNA repair activity in these patients.

• REC name

  HSC REC A

• REC reference

  19/NI/0087

• Date of REC Opinion

  17 Apr 2019

• REC opinion

  Further Information Favourable Opinion