Decellularisation of tissues for use as scaffolds in ortho repair.
Research type
Research Study
Full title
Development and characterisation of the process of decellularisation of human orthopaedic tissues for use as scaffolds for autologous cells in tissue repair.
IRAS ID
153763
Contact name
Gillian McNally
Contact email
Sponsor organisation
Tissue Regenix Group
Research summary
Summary of Results
The purpose of this project was to verify the decellularisation of human meniscus and tendon tissue when processed using the Tissue Regenix patented dCELL® process. In addition, the project was to compare the functional, biochemical and biomechanical properties of unprocessed and decellularised human meniscus and tendon tissue.
Despite a significant amount of development, processes which could consistently decellularise human meniscus or human tendon tissue to the level required were not established.
Several methods for testing of human meniscus and tendon tissue were developed and validated as part of this project, including methods for biomechanical testing, quantification of residual DNA, histological analysis and bioburden testing.
Due to changing business priorities, further investigation into development of decellularised human meniscus and tendon products was discontinued. Any remaining samples of human tendon and meniscus tissue held by Tissue Regenix were disposed of in November 2020.REC name
London - Camden & Kings Cross Research Ethics Committee
REC reference
14/LO/0633
Date of REC Opinion
8 Apr 2014
REC opinion
Favourable Opinion