Decellularisation of bone

• Research type

  Research Study

• Full title

  Acellular human bone allograft as a repair material for bone defects

• IRAS ID

  249393

• Contact name

  Anthony Herbert

• Contact email

  a.herbert@leeds.ac.uk

• Sponsor organisation

  University of Leeds

• Duration of Study in the UK

  2 years, 0 months, 1 days

• Research summary

  The purpose of this research is to decellularise allogeneic bone from the femoral heads, humeral heads and proximal tibias of living and deceased donors and to study the effects of the decellularisation process by determining the biological, structural, and mechanical properties. This will yield three different types of decellularised bone grafts. The overall aim of the project is to then define the most appropriate decellularised bone graft to replace particular bone defects, by matching the bone graft mechanical properties to the properties of the bone at the site of replacement. This will enable translation of the protocol into a Good Manufacturing Practice (GMP) Standard Operating Procedure (SOP) and to transfer the SOP to NHS Blood and Transplant Tissue and Eye Services (NHS BT TES) to introduce as a new clinical product range for clinical transplantation purposes.

• REC name

  London - London Bridge Research Ethics Committee

• REC reference

  18/LO/1534

• Date of REC Opinion

  25 Sep 2018

• REC opinion

  Favourable Opinion