DECADENT-HV V1.0
Research type
Research Study
Full title
Deriving cardiac reference ranges at 3.0Tesla in healthy volunteers (DECADENT-HV)
IRAS ID
288828
Contact name
Kenneth Mangion
Contact email
Sponsor organisation
NHS Greater Glasgow and Clyde
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Current MRI society guidelines recommend that reference ranges for specific imaging techniques (T1, T2 mapping, perfusion) are acquired on the MRI scanner that clinical work and research studies are being carried out on. We propose to undertake 32 multi parametric stress cardiac MRI scans on healthy volunteers (50% female, 50% male) over the age of 18 years. These measurements are not yet available for the 3.0T Prisma scanner at the Institute of Clinical Excellence (ICE), Queen Elizabeth University Hospital (QEUH). These values are essential to identify what is abnormal for people living in the west of Scotland.
1 – CISCO-19 study - Cardiac Imaging in SARS Coronavirus disease-19. Chief Scientist Office (ClinicalTrials.gov identifier is NCT04403607.) (Co-I: Berry, Mangion, Morrow, Roditi)
2- PRIZE study-Precision medicine with Zibotentan in microvascular angina. Medical Research Council (MR/S018905/1). (ClinicalTrials.gov registration for this study is NCT04097314) (Co-I: Berry, Morrow, Mangion)
3- Markers and Mediators of Angiogenesis inhibitor-induced vascular and myocardial toxicity. Heart Foundation (PG/19/64/34434). (Co-I: Mangion, Roditi)
4- Investigating the long-term cardiac sequelae of trastuzumab therapy. Tenovus Scotland (S20-08) (Co-I: Mangion, Berry, Roditi)REC name
West of Scotland REC 1
REC reference
21/WS/0122
Date of REC Opinion
27 Oct 2021
REC opinion
Further Information Favourable Opinion