DEA-MVTI
Research type
Research Study
Full title
Developing an Engineering Analysis of the Mitral Valve to help design new devices for Transcatheter Implantation (DEA-MVTI)
IRAS ID
219727
Contact name
Benedetta Biffi
Contact email
Sponsor organisation
Royal Free Hospital
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
BACKGROUND - Minimally invasive procedures for the treatment of heart valve disease are now a reality for the aortic and pulmonary valve: a new valve is inserted into the diseased heart via a catheter, thus sparing an open-heart operation to the patient. Despite increased demand, there are no such devices available for the mitral valve (MV). This is due to the extremely complex shape of the MV which sits within the heart in connection with various structures.
AIM - We propose to develop on the computer image elaboration techniques and engineering analysis to fully understand the characteristics of the MV in those patients requiring a new valve. In order to develop such techniques, detailed images of the MV and the surrounding structures have to be acquired in the target patient population. Providing a realistic setting for developing and testing our computational framework, real patient images will help to gain a full understanding of the variations of the MV shape and a complete classification of diseased valves, which will ultimately highlight the specifications to guide the development of a new MV device or to optimise existing designs. Using computer simulations, we will virtually implant MV devices into a model of the heart for every patient that we have classified as in need of a new valve. The computer simulation will aid the design process because the new device will be tested in realistic anatomies, thus shortening development time.
METHODS- Three dimensional (3D) transoesophageal echocardiography (TOE) and cardiovascular magnetic resonance (CMR) images will be acquired at Royal Free Hospital, London in n=30 patients with MV regurgitation, and processed offline for this study. More specifically, TOE is currently part of the standard NHS clinical workup for this class of patients, while a further CMR study will be added in the consenting patients.REC name
London - Central Research Ethics Committee
REC reference
17/LO/1080
Date of REC Opinion
5 Jul 2017
REC opinion
Favourable Opinion