DBS and Respiration
Research type
Research Study
Full title
Deep Brain Stimulation in Parkinson's Disease: Respiratory Testing
IRAS ID
256825
Contact name
Alexander L Green
Contact email
Sponsor organisation
University of Oxford / Clinical Trials and Research Governance
Duration of Study in the UK
3 years, 0 months, 4 days
Research summary
Parkinson's disease patients are routinely referred to the Functional Neurosurgery team in Oxford for deep brain stimulation. Anecdotal evidence, and a prior questionnaire study indicate that stimulation of the subthalamic nucleus may cause breathlessness in these patients. This study will aim to recruit those who are planning to undergo neuromodulation of the subthalamic nucleus. We also recruit control participants who are planning to undergo DBD of other brain targets. The research will involve one session before, and one session 3-6 months after surgery, where questionnaires will be administered and the respiratory system tested. This includes measuring of lung function, breathing dynamics and perception of breathlessness. They will be given a wrist exercise monitor to wear for up to 10 days before and after surgery, to provide an objective measure of activity. There will also be an option for an additional session to measure brain activity, and an option to be contacted in the longer-term for follow up with a questionnaire. The additional session will be carried out shortly after the surgery as in-patients, in the minority of patients whose stimulator systems are externalised post-operatively. Recordings will be taken from the system while respiratory testing is carried out. Patient with co-morbid obstructive sleep apnoea will be offered the opportunity of spending 2 or 3 nights in the sleep lab, to see if asleep breathing has been altered by DBS.
REC name
East of England - Cambridge East Research Ethics Committee
REC reference
19/EE/0094
Date of REC Opinion
19 Jun 2019
REC opinion
Further Information Favourable Opinion