Cytosorb filter in patients having surgery for infective endocdarditis
Research type
Research Study
Full title
Non Randomised Evaluation of Systemic Cytokine reduction for patients Undergoing Cardiopulmonary Bypass for Endocarditis Surgery
IRAS ID
206568
Contact name
Sunil Ohri
Contact email
Sponsor organisation
Southampton University Hospital
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Patients with an infection on one or more of their heart valves usually need open heart surgery to replace the valve. This is commonly associated with an intense inflammatory reaction that can lead to organ dysfunction/ failure [kidney, lungs, liver etc] and death. Preliminary evidence suggests that the use of a filter during the operation can prevent or reduce the inflammatory reaction. We plan to do this research to show if the cytosorb filters can reduce the infilammatory markers in the blood of patients with active infective endocarditis which will be reflected on the overall outcome. Consenting patients will allocated to one of two groups standard surgery using cardiopulmonary bypass (CPB) or CBP using cytosorb filter. It will be conducted at cardiothoracic center, Southampton university hospital, we anticipate it may take up to 2 year to recruit 20 patients.
REC name
South Central - Hampshire A Research Ethics Committee
REC reference
17/SC/0377
Date of REC Opinion
23 May 2018
REC opinion
Further Information Favourable Opinion