Cytokines, POD, Health status, Older Hip Fracture

• Research type

  Research Study

• Full title

  Perioperative cytokines, postoperative delirium and health status in older people undergoing hip fracture surgery - a pilot study

• IRAS ID

  299412

• Contact name

  Iain Moppett

• Contact email

  iain.moppett@nottingham.ac.uk

• Sponsor organisation

  University of Nottingham

• Duration of Study in the UK

  0 years, 11 months, 30 days

• Research summary

  This is an observational cohort study on factors associated with the risk of developing postoperative delirium (POD) and subsequent self-reported health related quality of life (HR-QoL) in cognitively intact people, age 65 years and above, undergoing hip fracture surgery.
  The study aims to identify if the magnitude and direction of change in serum cytokine levels across the anaesthesia/surgical intervention is associated with the incidence of postoperative delirium and subsequent HR-QoL status. We will also assess the effect of retinal layer thickness and frailty, on the association between cytokine levels and POD. Finally we will assess the association between severity of POD and subsequent HR-QoL.

• REC name

  London - Bromley Research Ethics Committee

• REC reference

  21/LO/0850

• Date of REC Opinion

  25 Nov 2021

• REC opinion

  Favourable Opinion