Cytokine guided Robotic Urological Surgery
Research type
Research Study
Full title
Cytokine guided Robotic Urological Surgery
IRAS ID
187939
Contact name
Nikhil Vasdev
Contact email
Sponsor organisation
East and North Herts NHS Trust
Duration of Study in the UK
0 years, 6 months, 0 days
Research summary
Aim of Study
When patients undergo a minimally invasive operation be it laparoscopic ('keyhole surgery') or robotic the technique of either procedure involves the creation of an abnormal presence of air or other gas with Carbon Dioxide at the beginning of the procedure in order to create the surgical field (space within the abdominal cavity). There is no standard pressure for the Carbon Dioxide used to create this space therefore this can vary considerably. Due to this elevated pressure in the abdomen, the patient can develop a degree of “closed compartment syndrome” meaning excessive pressure can prevent the flow of blood to and from the affected tissues.Certain patients develop a lack of movement in the intestinal wall (paralytic ileus) after robotic surgery. This results in an inadequate blood supply to the gut (gut ischemia) which leads to increased cytokine (proteins) release.
We aim to evaluate and measure the different levels of Cytokines at the different stages of the surgical pathway, therefore predicting the post-operative course and management of individual treatment for patients. It is hoped that we determine if we can predict the post-operative management of an individual patient in the future and know if the need for intravenous fluids would be prolonged.
REC name
East of England - Cambridge East Research Ethics Committee
REC reference
16/EE/0488
Date of REC Opinion
9 Nov 2016
REC opinion
Further Information Favourable Opinion