Cytokine-guided Robotic Cystectomy (CY-ROC)
Research type
Research Study
Full title
Diagnostic Accuracy of increased serum cytokine levels as a marker of paralytic ileus following Robotic Radical Cystectomy
IRAS ID
253466
Contact name
Nikhil Vasdev
Contact email
Sponsor organisation
East and North Hertfordshire NHS Trust
Duration of Study in the UK
0 years, 6 months, 0 days
Research summary
Cytokines are signalling proteins that are release by immune cells in response to stress on the body. In this study we aim to evaluate the concordance between cytokine rise (specifically monitoring the following cytokines: IFN-gamma, TNF-alpha, IL-1beta, IL-2, IL-4, IL-6, IL-12 and IL-17) and postoperative ileus (a condition where bowel function slows causing build up of faecal matter) following robotic radical cystectomy and the pneumoperitoneum (gas insufflation of the abdomen) pressures that were required intra-operatively.
We plan to perform an observational study involving 20 patients undergoing radical cystectomy. We plan to measure pre-anaesthetic, post-anaesthetic, immediately post-operatively and two further post-operative serum cytokines levels and compare them with the pneumoperitoneal pressures required intra-operatively and the outcome of whether a clinical diagnosis of paralytic ileus was made.
No alterations will be made to the care of the patient, this is purely an observational study.
REC name
South West - Cornwall & Plymouth Research Ethics Committee
REC reference
18/SW/0250
Date of REC Opinion
2 Nov 2018
REC opinion
Further Information Favourable Opinion