Cytokine clearance in AKI (ClicAKI)
Research type
Research Study
Full title
Clearance of inflammatory cytokines in patients with septic acute kidney injury during renal replacement therapy using the EMIC®2 filter (ClicAKI)
IRAS ID
196972
Contact name
Marlies Ostermann
Contact email
Sponsor organisation
Guy's & St Thomas' Hospital
Clinicaltrials.gov Identifier
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Sepsis is the inflammatory response to an infection. It can cause poor function of all organs and can be life threatening. Critically ill patients with sepsis and acute kidney failure have a particularly high risk of dying. A proportion of patients with acute kidney failure need dialysis treatment to remove excess fluid and toxins. \n\nThe EMiC®2 filter is a new dialysis filter with slightly larger pores than conventional filters. As a result, larger molecules can be removed during dialysis. The filter is fully approved for use and has been shown to be safe in previous small studies. It is routinely used in some hospitals in Europe.\n\nThe aim of our pilot study is to investigate whether the EMiC®2 filter can remove cytokines which are inflammatory molecules produced in sepsis. We plan to measure different pro- and anti-inflammatory cytokines at different time points in 10 patients with sepsis who are treated with acute dialysis. \n\nWith consent, we plan to take a blood sample before acute dialysis is started. Whilst on acute dialysis we plan to take further blood and dialysate samples at different time points up to 52 hours.In total we will take no more than 27mls of blood and up to 30mls of dialysate. The amount of blood taken will not cause any harm to the patient; dialysate fluid is usually discarded. \nThere will be no change in treatment or clinical management. \n\nThe results of this pilot project will help us to decide whether further studies are necessary to investigate the benefit and risks of removing cytokines in patients with sepsis and acute kidney failure.
REC name
London - Camden & Kings Cross Research Ethics Committee
REC reference
16/LO/0313
Date of REC Opinion
27 May 2016
REC opinion
Further Information Favourable Opinion