Cystatin C Measurement in Nutrition Support Patients
Research type
Research Study
Full title
Cystatin C Measurement in Nutrition Support Patients
IRAS ID
230339
Contact name
Paul Knight
Contact email
Sponsor organisation
UHSM
Duration of Study in the UK
0 years, 6 months, 18 days
Research summary
Adult estimated renal function today is calculated from serum creatinine levels. Creatinine is dependent on muscle mass. Patients receiving nutrition support are often undernourished and can also have reduced muscle mass potentially leading to a false impression of renal function i.e that it is better than it actually is. Cystatin C can be measured in serum, used to calculate and estimate renal function, and is not affected by muscle mass. However this has not been studied in the adult nutrition support cohort.
It is intended that we look at hospital nutrition support patients in the University Hospital of South Manchester (UHSM) and Salford Royal (SRFT) Foundation Trusts with an overall objective of comparing Cystatin C based calculated renal function with calculated creatinine based renal function by MDRD, Cockcroft-Gault, CKD-EPI and 24 hr urine creatinine clearance.
It is intended that we use routine "anthropometric" measurements carried out on nutrition support patients to assess whether the patients are demonstrably undernourished. We will use patients receiving nutrition support who are well nourished as our controls. We will need to measure thyroid function to make sure that it is normal as there is some evidence of an effect of abnormal thyroid function on cystatin C.
The alternative hypothesis will be that cystatin C is a more reliable marker of renal function in undernourished nutrition support patients than creatinine based methods.
This is worth doing because hospitals with malnourished patients may miss those with renal problems or not pick them up at an early enough stage to be able to intervene. On safety grounds we therefore need to establish if renal function in this patient group should be carried out via Cystatin C based calculations. This is not done routinely and evidence would be needed to justify the cost of analysis.REC name
Yorkshire & The Humber - Sheffield Research Ethics Committee
REC reference
17/YH/0251
Date of REC Opinion
27 Jul 2017
REC opinion
Further Information Favourable Opinion