CURED Feasibility Trial - V1.0
Research type
Research Study
Full title
Cognitive Bias Modification Utilized to Rectify Errors for Depression (CURED): A randomised double-blind feasibility trial - V1.0
IRAS ID
336376
Contact name
Jenny Yiend
Contact email
Sponsor organisation
King's College London
Clinicaltrials.gov Identifier
N/A, N/A
Duration of Study in the UK
1 years, 5 months, 18 days
Research summary
This study aims to answer the following research question: Is CURED, a recently developed depression-focused CBM-I procedure, feasible to be administered and effective in reducing depressive symptoms? In addition, the effectiveness of the CURED in reducing interpretation bias, negative imagery characteristics, negative self-related cognitions, and anxiety will be tested. The study will first test the readability and negativity of the treatment items in a pilot trial as an a priori manipulation check (10 individuals with clinical experience, 8 individuals with lived experience of depression, N = 18). This will be followed with a 2 (Intervention / Control) x 3 (Measurement times) mixed design feasibility trial. While main outcomes will be measured at 3 time points (baseline, post-treatment, and a follow-up at 6 weeks after the last training session), some measures will also be delivered after each training session (6 measurements in total). A total of 60 participants who meet the DSM 5 diagnostic criteria for major depressive disorder will be recruited. The study will be conducted at 1 NHS site, South London and Maudsley (SLaM) and 1 Educational Institute (IoPPN). The research is funded through the student's (Mr Kaan Alp Karamanli) PhD scholarship from the Ministry of Education of Turkey. Additionally, a qualitative interview will be conducted with those who volunteer and participate in the intervention condition to learn the participant's perspective on the intervention.
REC name
London - Fulham Research Ethics Committee
REC reference
24/LO/0855
Date of REC Opinion
19 Mar 2025
REC opinion
Further Information Favourable Opinion