Culturing nasal epithelial cells in patients with bronchiectasis
Research type
Research Study
Full title
Culturing nasal epithelial cells in patients with bronchiectasis
IRAS ID
233334
Contact name
Adam T Hill
Contact email
Sponsor organisation
University of Edinburgh
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Bronchiectasis is a chronic lung condition with patients having regular cough, regular sputum production and prone to recurrent chest infections. The majority of patients have chronic infection in the airways.
We have a PhD student investigating Haemophilus species in bronchiectasis (an organism frequently identified in bronchiectasis) and the ability of the organism to stimulate an inflammatory response on cells similar to the ones that line the human airways (epithelial cells) in the laboratory.
We have done experiments on an epithelial cell line but want to see if similar effects are found when we culture nasal epithelial cells from patients with bronchiectasis.
The plan in this study is to isolate nasal epithelial cells from nasal brushings from patients with bronchiectasis and grow the epithelial cells in the laboratory and then do experiments in the laboratory to see if the bacteria in the presence of these cells causes inflammation.
We are recruiting 10 patients from the bronchiectasis service at the Royal Infirmary of Edinburgh. Each participant that agrees to take part will have a nasal brush passed into the nose. The procedure is quick and will be over in under 30 minutes.
There is no external funding for this study.
REC name
West of Scotland REC 1
REC reference
17/WS/0225
Date of REC Opinion
8 Jan 2018
REC opinion
Further Information Favourable Opinion