CTP-PRO
Research type
Research Study
Full title
Impact of stress Cardiac computed Tomography myocardial Perfusion on downstream resources and PROgnosis in patients with suspected or known coronary artery disease: a multicenter international study - CTP-PRO Study
IRAS ID
301010
Contact name
Richard Crawley
Contact email
Sponsor organisation
Centro Cardiologico Monzino, IRCCS
Clinicaltrials.gov Identifier
Duration of Study in the UK
3 years, 4 months, 31 days
Research summary
Coronary artery disease (CAD) is one of the main causes of death worldwide, defined as an interruption to the heart's blood supply. Computed Tomography Coronary Angiography (CTCA) is a first-line non-invasive diagnostic test in the UK to identify patients affected by CAD, as per NICE guidelines. However, a significant proportion of CTCA scans result in the identification of mild or moderate severity CAD; often leading to further functional tests to establish whether patients would benefit from invasive treatments, such as percutaneous coronary intervention or coronary artery bypass grafting.
Cardiac CT perfusion imaging (CTP) is a newly developed technique, combining anatomical and functional imaging into a single modality. In previous clinical trials, combined CTCA/CTP has showed additional diagnostic value compared with CTCA alone.
CTP-PRO is a multicentre, prospective, randomised-controlled trial evaluating the cost-effectiveness of a combined CTCA + CTP strategy versus alternative non-CT investigations in patients with suspected or known CAD referred for diagnostic evaluation.
All participants recruited will be adult patients within the NHS with known CAD or intermediate-to-high risk of CAD. Consenting patients will be randomised into two groups (1:1 ratio):
- Those within Group A will be investigated via CTCA. When CTCA demonstrates a significant coronary stenosis (>50% stenosis in one or more coronary arteries), the participants will progress to additional CTP imaging.
- Those randomised to Group B will undergo an alternative non-CT-based investigation for CAD. As NICE guidelines recommend functional testing first-line in these patients, those within this arm are assumed to be within the ‘standard of care’.CTP-PRO is an international collaboration between research centres across Europe and the USA, assessing the potential for combined CTCA/CTP testing within multiple healthcare settings. At present, CTP is not performed routinely in the UK for investigation of CAD; this study presents a unique opportunity to evaluate this novel strategy within NHS patients.
REC name
London - Bromley Research Ethics Committee
REC reference
21/LO/0570
Date of REC Opinion
23 Nov 2021
REC opinion
Further Information Favourable Opinion