ctDNA v6.0
Research type
Research Study
Full title
Circulating tumour DNA (ctDNA) rectal cancer and the relationship to extramural venous invasion
IRAS ID
136894
Contact name
Gina Brown
Contact email
Sponsor organisation
Imperial College London and Imperial College Healthcare NHS Trust
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Cancer cells can be shed by primary rectal tumours and detected in venous blood by measuring levels of circulating cell free tumour DNA (ctDNA). These cells are almost never found in healthy subjects. It is thought that levels of ctDNA are related to disease progression as patients with metastatic disease demonstrate higher values of ctDNA. This study aims to evaluate the levels of ctDNA in the blood during the treatment of rectal cancer to determine whether there is a link between ctDNA levels and the amount of tumour spread into the rectal veins(EMVI) seen on pelvic MRI. Blood will be taken after chemoradiotherapy and again during surgery.
REC name
South Central - Oxford B Research Ethics Committee
REC reference
15/SC/0491
Date of REC Opinion
30 Sep 2015
REC opinion
Further Information Favourable Opinion