CTCA before CTO PCI
Research type
Research Study
Full title
Computed Tomography Coronary Angiography (CTCA) prior to Chronic Total Occlusion (CTO) Percutaneous Coronary Intervention (PCI) - a feasibility study
IRAS ID
293244
Contact name
Vinoda Sharma
Contact email
Sponsor organisation
SWBH NHS Trust
Clinicaltrials.gov Identifier
Duration of Study in the UK
1 years, 0 months, 31 days
Research summary
Chronic Total Occlusion (CTO) of a coronary artery refers to an artery that has been completely blocked for a while, usually >3 months. There are different
grades of complexity of the blockage with higher numerical numbers indicating more severe blockage/complexity.
Previously, these patients with total coronary occlusion were referred for coronary artery bypass graft (CABG) surgery but in the last 10-12 years, new tools and techniques have paved the way for percutaneous (Percutaneous Coronary Intervention or PCI, also called stenting or angioplasty) options for opening up these arteries with success rates of 70%-80%.
Despite this, the procedure can take a long time to complete (2-4 hours) and may sometimes require more than one procedure in the more complex cases for successful completion.
When the procedure is unsuccesful, on many occasions a CT scan of the coronary arteries (CT coronary angiogram or CTCA) is requested after the failed CTO PCI procedure. The CTCA provides information on the architecture of the blocked artery which on ad-hoc basis has been found to be useful when undertaking a CTO procedure.
We aim to undertake a feasibnility study to demonstrate the utility of CTCA prior to attempting opening up the chronically occluded artery (CTO).
The study will be performed by randomising patients to having a CTCA or no CTCA prior to the CTO PCI attempt.
We anticipate that performing the CTCA first will guide the operator to techniques, reduce the time taken for the procedure,improve success rates and consequently improve patient's symptoms.REC name
West Midlands - South Birmingham Research Ethics Committee
REC reference
21/WM/0271
Date of REC Opinion
3 Mar 2022
REC opinion
Further Information Favourable Opinion